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KMID : 0624219930010000022
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Focus on Genetic Science
1993 Volume.1 No. 0 p.22 ~ p.30
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Role of Human Papillomavirus and p53 Tumor Suppresser Gene in Cervical Carcinogenesis
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Kim Kun-Hong
Kim Yoon-Soo
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Abstract
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The correlation between human papillomavirus (HPV) infection and tumor suppresser gene, p53 mutation in the progression of cervical carcinogenesis was elucidated. Sixteen out of 25 cervical cancer patients showed HPV DNA positive while one out of 3 normal subjects showed HPV positive. Amplification of various regions (exons 5,6,7,8) of p53 gene by polymerase chain reaction has been performed and the amplified DNAs were confirmed as to be the DNA sizes expected when they were subjected to agarose gel electrophoresis. Determination of the mutation of p53 and type of HPV in samples of patients is under study.
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KEYWORD
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